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management algorithm cll hemolytic leukemia lymphocytic aplastic cold erythematosus extravascular gap globulin hemeonc hemolysis hodgkins intravascular lupus lymphoma myelodysplasia myelodysplastic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... symptoms - most common ... Blood smear - RBC ... younger pts) Differential ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... . primary cold agglutin ... #differential # ... diagnosis #hematology ... #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... hemolysis, deficiency anemia ... • Infections: Chronic ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Overview: • Most common ... chemotherapy for low-risk disease ... #Leukemia #oncology ... #hematology #hemeonc
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... • ↓ WBC • ↓ ... Treatment: ... #oncology #hematology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Workup ... platelets - WBC ... number of sites of disease ... Hodgkin Lymphoma Treatment ... #hematology #oncology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Better call hematology ... normal/high - Chronic ... , think about common ... #workup #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... common • Antihistone ... with Lupus: • Chronic ... #Rheumatology
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