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hematology management mds myelodysplastic anemia chronic cll differential gap lymphocytic lysis myelodysplasia protein proteingap syndromes tumor
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
aplasia • ITP ... increase in gamma globulins ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... = funny-shaped cells ... transformation to acute leukemia ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... • ↓ WBC • ↓ ... anemia Treatment ... antithymocyte globulin ... #oncology #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... • Lab values: WBC ... leukapheresis - TLS ... Lysis of tumor cells ... #TLS #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Causes • Anemia • Aplastic ... • Hairy Cell Leukemia ... #diagnosis #hematology ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... leukemia • Solitary ... changes (POEMS syndrome ... #differential #diagnosis
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