11 results
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... von Willebrand syndrome ... diseaseWarfarin ... PT/ABNORMAL PTT ... #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
manifestations: from easy bruising ... Petechial or purpuric rash ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... #Causes #diagnosis ... #differential # ... hematology #coagulation
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... Noninfectious hepatitis ... to: Arthritis, Fever ... #Diagnosis #Rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Anticoagulants (Warfarin ... deficiency • Liver ... mountain spotted fever ... #Diagnosis #hematology ... #rheumatology #
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Liver disease ... - Alcoholic hepatitis ... Mediterranean fever ... #differential # ... hepatology #SAAG
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... vein: Budd-chiari syndrome ... function may be abnormal ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
NASH, Chronic ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Coronary arteries - Fever ... mucositis - Rash ... systemic lupus erythematosus ... Vasculitis: • Fevers ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... ischemia • Skin: Erythematous ... , mucositis • Rash ... fluid (CSF) is abnormal ... #Diagnosis #Rheumatology