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anemia management algorithm blood product reactions bruising common cryofibrinogenemia cvid extravascular hemostasis hypogammaglobulinemia immunodeficiency immunology injury intravascular nonpalpable palpable purpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... Intravascular Hemolysis ... agglutin disease ... #differential # ... diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... Diagnosis: • hemolytic ... • Compensated hemolysis ... #hemolytic #anemia ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... agglutinins disease ... hemolysis) ARUPConsult ... @ARUPLabs #Hemolytic ... #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... : Warm AIHA, Cold ... Defects, Drugs, Liver ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis ... • Hemolysis ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis ... #hepatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Febrile Non-Hemolytic ... • Acute Hemolytic ... to hemolysis & ... Hemolysis on labs ... #management #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and hepatitis ... hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
associated with autoimmune ... , vasculitis, sepsis ... • Warfarin-induced ... #rheumatology # ... hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Acute Hemolytic ... to hemolysis & ... Hemolysis on labs ... , minor hemolysis ... #management #hematology
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