29 results
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Diagnosis Algorithm ... Platelet Function ... - Acquired • Anticoagulation ... Iatrogenic) • Liver ... #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Anticoagulants (Warfarin ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Reversal Agents - Warfarin ... PCC (Kcentra) - Heparin ... PCC (Kcentra) #anticoagulation ... #doac #noac #pharmacology ... #hematology #reversal
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Thrombocytopenia - Differential ... Diagnosis Algorithm ... Connective tissue disorders ... #Diagnosis #Algorithm ... #hematology #platelets
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders ... - Differential ... • Production: Liver ... #Disorders #Differential ... #Diagnosis #hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... 1 or Type 3) — differentiate ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Medications - Heparin ... , LMWH, warfarin ... ) • Advanced Liver ... table #comparison #diagnosis ... #hematology #deficiency
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Disorders - Differential ... Diagnosis and Workup ... : INR/PT, aPTT(liver ... #Disorders #Differential ... #Workup #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
clot #PT #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation ... anticoagulant #Warfarin ... Rivaroxaban #Edoxaban #heparin
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... without platelet ... MYH9-Related Disorder ... comparison #table #differential ... #diagnosis #hematology