35 results
Causes of Thrombocytopenia.
Platelet counts may be depressed because of decreased production or due to increased platelet
Causes of Thrombocytopenia ... Platelet counts ... #Diagnosis #Hematology ... #Thrombocytopenia ... #Differential #
Approach to suspected Heparin-Induced Thrombocytopenia (HIT)

 • Suspected HIT Algorithm
 • "4 T's" clinical probability score:
(platelet count ... Timing of onset of platelet ... NephPrasad #Heparin ... #HIT #hematology ... #diagnosis #4Ts
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Anticoagulants (Warfarin ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Thrombocytopenia ... Sequestration Disordered Platelet ... - Acquired • Anticoagulation ... Iatrogenic) • Liver ... #Causes #Hematology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Reversal Agents - Warfarin ... PCC (Kcentra) - Heparin ... PCC (Kcentra) #anticoagulation ... #doac #noac #pharmacology ... #hematology #reversal
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Thrombocytopenia ... - Differential ... Diagnosis Algorithm ... #Differential # ... #hematology #platelets
4-T Score for the Likelihood of Heparin Induced Thrombocytopenia
 - Thrombocytopenia - Compare the highest platelet
count
Likelihood of Heparin ... Compare the highest platelet ... - Timing (of platelet ... #Likelihood #Diagnosis ... #Hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... chain IIA • Thrombocytopenia ... fibrinogen) • Thrombocytopenia ... comparison #table #differential ... #diagnosis #hematology
4T Score for Heparin-Induced Thrombocytopenia

Interpretation of the 4T score:
0-3 points:  Low probability (<<1%)
  -
Thrombocytopenia ... Consider therapeutic anticoagulation ... HeparinInduced #Thrombocytopenia ... #Diagnosis #Criteria ... #Hematology
Thrombocytopenia - Differential Diagnosis and Management Framework for Low Platelets

#Thrombocytopenia #Differential #Diagnosis #Management #hematology #platelets
Thrombocytopenia ... - Differential ... Diagnosis and Management ... #Differential # ... #hematology #platelets