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diagnosis hematology causes differential management anemia activation agglutinin chronic cll cold cushings disorders endocrinology extravascular hemeonc hemolysis hemophagocytic hlh hypercortisolism
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) - HELLP syndrome ... uremic syndrome ... . primary cold agglutin ... #hematology #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... test #cold # ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... , ANA (e.g., SLE ... unclear, or if a primary ... #hematology
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Hypertension - Workup ... and Differential Diagnosis ... renal bruit or signs ... Hypothyroidism, Primary ... Renal parenchymal disease
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... • Or brainstem syndromes ... Multiple Sclerosis Diagnosis ... criteria for MS ... Progressive MS • Primary
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Infection (eg ... Liver function tests ... Histopathologic criteria ... #Diagnosis #Management ... #Hematology #Rheumatology
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
Cushing's Syndrome ... Hypercortisolism - Diagnosis ... not a feature of primary ... dexamethasone suppression test ... #signs #symptoms
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Physical Exam/Signs ... cells can indicate disease ... #workup #oncology ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Types of HLH • Primary ... ▪ Autoimmune diseases ... Presentation • Common Signs ... Diagnostic Criteria ... of 8 HLH-2004 criteria
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