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diagnosis hepatology algorithm lfts transaminitis management aclf acute chemistry classification dermatology dili druginduced encephalopathy failure function gastroenterology grading hepatic hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... months without treatment ... Injury (DILI) ... #Cirrhosis #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... • NAFLD • Cirrhosis ... • Chronic Viral ... injury) • Ischemic ... #Diagnosis #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Nonalcoholic fatty liver ... heart failure (chronic ... #Diagnosis #Differential ... #Hepatology #Cirrhosis ... #Causes
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 Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #Injury #hepatology ... transaminitis #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Algorithm Vascular Causes ... hepatitis: < 1 • Cirrhosis ... #differential #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
> 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
discoloration) • Liver ... cirrhosis • Congestive ... discoloration) • Chronic ... #Differential # ... Diagnosis #Algorithm #causes
Hepatic Encephalopathy - Diagnosis and Management Summary Definition: • Alteration in brain function manifested by neuropsychiatric symptoms
by liver insufficiency ... rule out other causes ... Prevalence: At cirrhosis ... Initiate empiric treatment ... #hepatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
pulmonary disorder of chronic ... triad of: 1) chronic ... arteriovenous shunting causes ... • Stigmata of cirrhosis ... #diagnosis #hepatology
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