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endocrinology diagnosis growthhormone acromegaly feedbackloop management overproduction pituitary symptoms treatment
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... GH excess after ... overgrowth: • Carpal ... Tunnel Syndrome ... #diagnosis #signs
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... excess: - ... expansion (e.g. carpal ... tunnel, OSA, Incr ... endocrinology #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
paresthesias (carpal ... tunnel) and OSA ... excess occurs before ... islet cell tumor, excess ... glucose suppression test
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