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endocrinology gh excess feedbackloop overproduction pituitary symptoms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... expansion (e.g. carpal ... tunnel, OSA, Incr ... metabolic abn #GrowthHormone ... endocrinology #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
overgrowth: • Carpal ... Tunnel Syndrome ... fraction • HTN #GrowthHormone ... Overproduction #diagnosis ... #signs #symptoms
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