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diagnosis management cppd disease pseudogout symptoms syndrome behcet chondrocalcinosis comatose comparison deposition differential fungal gout hematology infections infectiousdiseases leukostasis lysis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... treatment (no calcium ... diagnosis #management #hematology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
joints (shoulders, wrists ... disease states Pathophysiology ... precipitates with calcium ... knees, fingers, wrist ... Gout #Comparison #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
ulceration • Ocular ... skin injury) • Neurologic ... Leukemia, Lymphoma Ocular ... diagnosis #management #signs ... #symptoms #rheumatology
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
• Mutism Pathophysiology ... • Vestibulo-ocular ... • Examine for signs ... Arms extended; wrists ... #PhysicalExam #neurology
Chondrocalcinosis: Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease - Acute CPPD precipitation into the joint space ->
Chondrocalcinosis: Calcium ... affected — e.g., wrist ... CPPD #Disease #Signs ... #Symptoms #Pathophysiology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Disease (CPPD) Pathophysiology ... joints (shoulders, wrists ... often involves the wrists ... atypical locations: Wrist ... Deposition #Disease #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... affects the skin, neurologic ... cognitive impairment, neurologic ... Cogan syndrome: Ocular ... Differential #Diagnosis #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... by culture or serology ... Aspergillosis Pathophysiology ... osteoarticular, pulmonary, ocular ... Diagnosis: • Serology
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