9 results
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Kcentra) - Heparin/LMWH ... (Praxbind) - Apixaban ... PCC (Kcentra) #anticoagulation ... #doac #noac #pharmacology ... #hematology #reversal
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
#anticoagulation ... #INR #heparin #LMWH ... rivaroxaban #Xarelto #apixaban ... dabigatran #Pradaxa #management ... #pharmacology #
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... of cancer-associated ... anticoagulant; LMWH ... #Anticoagulation ... #Management #Hematology
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Weight Heparin (LMWH ... Xa inhibitors - Apixaban ... #pharmacology # ... medications #doac ... comparison #table #management
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
thrombosis in cancer ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... #Anticoagulation ... #Management #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... patients on chronic anticoagulation ... interruption per treatment ... inhibitor) • Apixaban ... #Treatment #pharmacology
Anticoagulant Bridging

 • Switching from LMWH
 • Switching from UFH
 • Switching from DOAC to Warfarin
Switching from LMWH ... Switching from DOAC ... Anticoagulant #Bridging #anticoagulation ... #pharmacology # ... management #hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... Antidotes: • Apixaban ... anticoagulant #hematology ... #management #pharmacology