10 results
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
joints (shoulders, wrists ... • Underlying disease ... states Pathophysiology ... precipitates with calcium ... Gout #Comparison #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
(CPPD) Pathophysiology ... joints (shoulders, wrists ... often involves the wrists ... atypical locations: Wrist ... #Rheumatology #
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
- Pathophysiology ... damage leading to calcium ... Calcium influx leads ... #Pathophysiology ... Complications #Hematology
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
> Clearance of calcium ... mineralization of calcium ... and/or x-ray - CPPD ... #Disease #Signs ... #Symptoms #Pathophysiology
Chondrocalcinosis: Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease

 - Acute CPPD precipitation into the joint space ->
Chondrocalcinosis: Calcium ... ) Deposition Disease ... affected — e.g., wrist ... #Disease #Signs ... #Symptoms #Pathophysiology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Symptoms of Joint Disease ... categories of joint disease ... dihydrate • Basic calcium ... Joint #Pain #MSK #rheumatology ... #approach #workup
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune disease ... distal to elbows/wrists ... interstitial lung disease ... Scleroderma #SSc #rheumatology ... symptoms #testing #workup
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... crystals (gout) or calcium ... profile (e.g., calcium ... Arthritis #laboratory #workup ... diagnosis #testing #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
thiazidic, PPI, ACE, calcium-b ... • Immunologic Workup ... • Immunologic Workup ... Evolution: Chronic disease ... comparison #table #rheumatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
nephrocalcinosis • CPPD ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... ALP -> PPi and Calcium