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diagnosis comparison differential hematology management pseudogout signs symptoms testing algorithm anemia calcium chondrocalcinosis deposition druginduced gap globulin gout hemolytic lupus
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune disease ... of Scleroderma (SSc ... distal to elbows/wrists ... #rheumatology # ... symptoms #testing #workup
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
joints (shoulders, wrists ... • Underlying disease ... states Pathophysiology ... knees, fingers, wrist ... Gout #Comparison #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
(CPPD) Pathophysiology ... joints (shoulders, wrists ... often involves the wrists ... atypical locations: Wrist ... #Rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell disease ... ): SS, SC, SE, Sβ ... , Hemoglobin H disease ... Diagnosis #Algorithm #workup ... #hematology #testing
Chondrocalcinosis: Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease - Acute CPPD precipitation into the joint space ->
) Deposition Disease ... - Acute CPPD ... affected — e.g., wrist ... #Disease #Signs ... #Symptoms #Pathophysiology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Anti-ENA - Rare (SSA ... • Immunologic Workup ... Evolution: Chronic disease ... comparison #table #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Heavy chain disease ... plasmacytoma • Castleman disease ... Sarcoidosis) • Liver disease ... hepatitis, PBC, PSC
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