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hepatology algorithm causes lfts ascites obstetrics saag abnormal albumin biliary chemistry cholangitis cirrhosis comparison enzymes gradient hellp hypertension icp injury
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... : • Defect in fetal ... Hepatitis, Preeclampsia ... #Fatty #Liver #
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... Liver of Pregnancy ... #Disease #Pregnancy ... #comparison #differential ... #diagnosis #icp
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Wilson's • Pregnancy ... - AFLP, HELLP ... • Cholestatic disease ... • Alcoholic hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... melanoma, myeloma • Pregnancy ... #differential # ... diagnosis #algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... of cholestatic disease ... disease: > 2 ... #chemistry #diagnosis ... #differential #
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Diagnosis Portal ... >10 mmHg - clinically ... Cirrhosis/acute hepatitis ... metastasis • Fatty ... liver of pregnancy
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Liver disease ... - Alcoholic hepatitis ... - Acute fatty ... liver of pregnancy ... #differential #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
obstruction • ALP ... or higher • Liver ... bile ducts Differential ... Viral hepatitis, ... cholestasis of pregnancy
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Gradient (SAAG) - Differential ... Diagnosis High ... - Alcoholic hepatitis ... - Acute fatty ... liver of pregnancy
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... disease; AST, aspartate ... non-alcoholic fatty ... liver disease; ... #Enzymes #Differential
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