10 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase (ALP ... ) Elevation - Differential ... Diagnosis Algorithm ALP ... - Increased ALP ... #Elevation #Differential
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
- Biliary tree ... Transaminase, ALP ... ≥ 2x ULN R Value ... ) / (ALP / ULN ALP ... Transaminitis #diagnosis #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... or AST > ALP): ... AIH, Wilsons, Pregnancy ... - AFLP, HELLP ... - CBD stone, Biliary
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... /ULN ALP) • R ... GGT/5-NT: ↑ • ALP ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
melanoma, myeloma • Pregnancy ... disease - If ALP ... both are normal, ALP ... hemolysis) • ALP ... diagnosis #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... • Wilson's • Pregnancy ... - AFLP, HELLP ... Duct Stone • Biliary ... Others #LFTs #Hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
(AFLP) Pathophysiology ... : • Defect in fetal ... infiltration) Differential ... iMedEducation #AFLP ... #hepatology #obstetrics
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
to 10-20-fold elevation ... (AFLP) • Onset ... #hepatology #obstetrics ... hepatitis #comparison #differential ... diagnosis #icp #HELLP #AFLP
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... obstruction • ALP ... bile ducts Differential ... cholestasis of pregnancy ... diagnosis #workup #hepatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
magnitude of enzyme elevation ... include extrahepatic biliary ... ALP, alkaline phosphatase ... Abnormal #Algorithm #Hepatology ... Liver #Enzymes #Differential