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diagnosis differential abnormal aptt intravascular prolonged treatment anemia blood comparison deficiencies deficiency disseminated extravascular hemolysis hemolytic hemophilia product reactions summary
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... Post-partum • Acute DIC ... comparison #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... (DIC) c. ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... #diagnosis #causes ... #treatment #management ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... (DIC) - HELLP ... (usually IgG) (e.g ... (usually IgM) (e.g ... differential #diagnosis #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... normal in mild cases ... ) • PT/INR & von ... hemophilia type (e.g ... #treatment #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... pain, dark urine, DIC ... Causes purpura & ... Transfusions #diagnosis #management ... #hematology #reactions
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