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management syndrome hematology rheumatology apml autoimmune causes differentiation erythematosus hyperviscosity leukostasis lupus lysis myopathy myositis oncology prs pulmonary renal sle
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... hyperleukocytosis (AML ... - MH/CCF/CWRU EM ... #Causes #Differential ... #Diagnosis #Treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... have fever - ACS ... lethargy, hematuria, cardiac ... with tetany or cardiac ... #TLS #diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... initiation • Differential ... unless severe APLS
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
(UPC) ratio • Cardiac ... EGPA • ESR and CRP ... o infection • Echocardiogram ... #differential # ... #treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (ACLE ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... 5% of patients Cardiac ... Cytopenias • Cardiac
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... Polymyositis or ALS ... < PM and DM • CPK ... • ANA < 20 % IBM ... weakness • Severe cardiac
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