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diagnosis clinical management dermatology differential hematology infectiousdiseases rheumatology blood cellulitis endocrinology fingernails infection infections nejm pathophysiology physicalexam product reactions sarcoidosis
Terry's Nails Proximal paleness extending halfway up the nail, often eliminating the lunula. Darker distal band. Seen
Terry's Nails ... advanced age, liver ... #Terrys #Fingernails ... PhysicalExam #Clinical #Photo
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
Anaplastic large cell ... sites (MC are skin ... tissue, lungs, liver ... subtle • Small cell ... Some isolated skin
Common organ involvements and symptoms in Sarcoidosis Lung 89-99% - Cough, dyspnoea, wheezing and stridor Skin 16-32% -
, wheezing and stridor ... Skin 16-32% - ... and vision loss Liver ... pain and elevated liver
Terry's Nails Patient of about 70 years, HIV positive, transplanted kidney donor cadaver in the previous 6
Terry's Nails ... studied) with liver ... spider angiomas and skin ... However, Terry's ... PhysicalExam #Clinical #Photo
Ulcerative Blastomycosis Skin Lesion 57 asymptomatic M from Indiana nonpruritic, painless, progressive skin lesion lower back x
Blastomycosis Skin ... Lives in an old ... differential: basal cell ... ca, squamous cell ... dermatology #clinical #photo
Syphilitic gummas in Tertiary syphilis Tertiary syphilitic gummas may mimic basal cell carcinoma. The gummatous tumors are
may mimic basal cell ... blood vessels, liver ... syphilis #clinical #photo
Vibrio vulnificus Infection- At the time of presentation, hemorrhagic bullae measuring 3.5 by 4.5 cm had
vulnificus can cause skin ... contaminated seawater, as well ... including chronic liver ... #clinical #photo
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... pathway -> Incr cell ... tunnel, OSA, Incr skin
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ulcerations • Skin ... disease and ILD • Liver ... Liver biopsies show ... CD4+ and CD8+ T cell ... 50% of cases • Skin
The Cell Cycle The cell cycle is the series of tightly regulated steps that controls cell growth
Cancer, in simplest terms ... at the cellular level ... Ever had bad sunburn ... your top layer of skin ... famously long lived
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