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diagnosis pathophysiology syndrome alkalosis chloride defects epithelial hypokalemia hyponatremia hypotonic inherited kidney management metabolic physiologic tubule urinary urine
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... recessive salt-losing ... thiazide-sensitive sodium-chloride ... Contraction → ↑ Renin ↑ Ca ... Pathophysiology #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
ascending limb Gitelman ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential ... #Table
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
hypokalemic salt-losing ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... ratio 0.5%) Differential ... Syndrome #diagnosis #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Urinary Chloride Algorithm ... Bartter syndrome, Gitelman ... settings, the urine sodium ... the excretion of sodium ... #nephrology #differential
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... : SIADH, Renal Sodium ... #Hyponatremia #differential ... #diagnosis #table ... #sodium #nephrology
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