841 results
Acute-phase Reactants Synthesized in the Liver 
Positive acute-phase reactants (concentrations increase with acute inflammation)
 - Immune-related
- Orosomucoid (alpha-I ... antienzymes) - Alpha-I ... A1-AT) - Alpha ... Synthesis #Hepatology #pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Medications
Aging
 -> Increased Testosterone -> Testosterone metabolized into DHT by type
-> LUTS - alpha ... smooth-muscle alpha ... Hyperplasia #Prostate #Pathophysiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
primarily) and block alpha ... Classification #Classes #pathophysiology
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
Phenylephrine (alpha ... beta1 > beta2 / alpha1 ... (D1 > beta1 > alpha1 ... • beta /mild alpha ... beta1 > beta2 > alpha1
The pathogenesis of idiopathic pulmonary fibrosis. 1 – In an initiating phase, there is lung alveolar
necrosis factor alpha ... #IPF #Pathophysiology
Pressors and Inotropes

Norepinephrine
 • alpha1 > beta 1
 • Increase SVR > Inotropy
Vasopressin
 • V1
 •
Norepinephrine • alpha1 ... Phenylephrine • alpha ... beta 1 and 2, alpha
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
primarily) and block alpha ... Classification #Classes #pathophysiology
Benign Prostatic Hyperplasia: Pathogenesis and Clinical Findings

Hormonal alterations (result of aging process)
    ->
conversion via 5-alpha-reductase ... Hyperplasia #Prostate #Pathophysiology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... macrophages produce 1-alpha
Adrenergic Receptors - Agonists and Antagonists
 • Alpha-1 Vascular
 • Alpha-2 Presynaptic
 • Beta-1 Heart
 •
Antagonists • Alpha ... 1 Vascular • Alpha