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Acute-phase Reactants Synthesized in the Liver Positive acute-phase reactants (concentrations increase with acute inflammation) - Immune-related - Complement (C') - Mannose-binding lectin (MBL) - C-reactive protein (CRP) - Orosomucoid (alpha-I acid glycoprotein) - Antiproteases (antienzymes) - Alpha-I antitrypsin (A1-AT) - Alpha-2 macroglobulin (A2M) - Antioxidants - Ceruloplasmin - Coagulation factors - Fibrinogen - Factor VIII Others - Haptoglobin - Serum amyloid A (SAA) - Plasma fibronectin - Lipopolysaccharide-binding protein (LBP) - Ferritin Negative acute-phase reactants (concentrations decrease with acute inflammation) - Retinol-binding protein (RBP) - Transthyretin (TBPA) - Albumin - Transferrin #AcutePhaseReactants #Synthesized #Liver #Synthesis #Hepatology #pathophysiology #Laboratory