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Pathophysiology of hypotonic hyponatremia

by Helbert Rondon, MD @NephroMD

#hypotonic #hyponatremia #nephrology #algorithm #Pathophysiology
Pathophysiology of hypotonic ... hyponatremia ... @NephroMD #hypotonic ... #hyponatremia # ... nephrology #algorithm
Hypo-osmolar Hypotonic HypoNatremia Algorithm (Serum Na+ < 135 meq/L, serum Osm < 275 mosm/kg)
Assess Volume Status,
Hypo-osmolar Hypotonic ... HypoNatremia Algorithm ... #Algorithm #Diagnosis ... #Nephrology #Differential ... #Hypotonic
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... water Extrarenal hypotonic ... salt intake: • Hypertonic ... Differential #Diagnosis #Causes ... #nephrology #sodium
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
Modified Hyponatremia ... Algorithm Hypertonic ... Urologic irrigants Hypotonic ... #Algorithm #diagnosis ... #sodium #nephrology
Hyponatremia with Severe Symptoms - Management Algorithm with Hypertonic Saline
The goal of acute management is to
Hyponatremia with ... Symptoms - Management Algorithm ... with Hypertonic ... Na causing the seizure ... #Saline #nephrology
Generalized Seizures and Pseudoseizures
Generalized seizures "are conceptualized as originating as some point within, and rapidly engaging,
Generalized Seizures ... caused by a toxic ... and metabolic causes ... hyperglycemia, hyponatremia ... Classification #Diagnosis #Neurology
Causes of Secondary / Provoked Seizures - Differential Diagnosis Algorithm
Febrile
Infection
 • Sepsis
 • Encephalitis
 • Meningitis
Metabolic
Causes of Secondary ... / Provoked Seizures ... Hypocalcemia • Hyponatremia ... #Neurology #Differential ... #Causes
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
Causes of Seizures ... Differential Diagnosis Algorithm ... Hyperglycemia, Hyponatremia ... Eclampsia, Prophyria #Seizures ... #Causes #neurology
Hyponatremia - Differential Algorithm
Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP
Hypotonic Hyponatremia: 
 • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Algorithm Isotonic ... , Recent TURP Hypotonic ... #Differential #Algorithm ... #diagnosis #causes ... #nephrology #sodium
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Causes of Hypernatremia ... Differential Diagnosis Algorithm ... 300 mmol/kg • Hypertonic ... #Nephrology #Differential ... #Causes