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Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
hypersensitivity reactions ... Mediators: lgE - Antigen ... Form: Soluble antigen ... Acute transfusion reaction ... hypersensitivity #reactions
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Definition: When antigens ... antibody-mediated immune reaction ... These antigens can ... either be self-antigens ... , or foreign antigens
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
to an allergic reaction ... • Type II - Antigenic ... against the antigen ... cell surface, and antigen-surface ... small antibody-antigen
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Sensitization -> Antigen ... class II) process antigen ... Primary Reaction ... Secondary Reaction ... after the primary reaction
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Penicillin-induced drug reaction ... Immunological Target: Antigen-Ab ... Dermatitis (ie. reaction ... Allergy #Allergic #Reactions
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE - Soluble antigen ... IgM - Cell-bound antigen ... IgM - Soluble antigen ... - Antigen-antibody ... Allergy #Diagnosis #Reactions
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... Macrophage engulfs antigen ... -> Antigen presentation ... cells recognize antigen
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
constipation • Allergic reaction ... mediated cytotoxic reaction ... to drug antigens
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... common immune reaction ... once had another reaction ... mismatch of donor antigens ... mismatch of minor antigens
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Delayed autoimmune reaction ... mimicry -> GAS antigen
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