6 results
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
/PTT • Low plasma ... protein C and S Pathophysiology ... /INR: ↑ • PTT: ... • Severe Liver ... INR < 2.3 - APTT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
and/or aPTT Prolonged ... typically prolong aPTT ... and aPTT 1. ... (DIC) c. ... Causes #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
and aPTT If the ... PT and the aPTT ... • Reduced liver ... #aPTT #Prolonged ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... /NORMAL PTT: Suggests ... PTT suggests liver
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... rapidly develops (DIC ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... #pathophysiology
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage - Differential ... Diagnosis and Management ... Oxytocin 40 IU in 1 liter ... epinephrine prn DIC ... /PTT • Treat with