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diagnosis coagulation anticoagulant apixaban cascade causes dabigatran dic disseminated edoxaban heparin inhibitor intravascular macrophage mas models pathophysiology pathway platelet rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
platelet #thrombin #clot ... #PT #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
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