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diagnosis hematology differential oncology hemolytic algorithm bands bloodcell cell chronic classification extravascular gap globulin hemolysis hodgkins intravascular leucocytosis leukemia leukemoidreaction
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... IgM associated lymphoma ... hematology #microscopy #atlas
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
the non-Hodgkin lymphoma ... Lymphocytosis on CBC ... lymphoproliferative disorders ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... thalassemia, S Lepore • Basophilic ... membrane disorder ... Diagnosis #Algorithm #workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) (e.g. lupus, CLL ... , lymphoma, idiopathic ... lymphoproliferative disorders ... • Intrinsic RBC
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
, monoblast, & lymphoid ... eosinophils, & basophils ... myeloproliferative disorders ... rickettsia infections, brucellosis ... the underlying cause
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Workup: • Full ... platelets - WBC
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... Connective tissue disorders ... • Hematology: Lymphoma ... anemia • Other
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... • No CRAB - no anemia ... • CBC + diff • ... • Non-Hodgkin Lymphoma ... Oncology #Diagnosis #Workup
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