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diagnosis hematology differential oncology hemolytic algorithm bands bloodcell chronic classification extravascular gap globulin hemolysis hodgkins intravascular leucocytosis leukemia leukemoidreaction lymphocytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... hematology #microscopy #atlas
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... lymphoproliferative disorders ... CLL Labs: 1. ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... thalassemia, S Lepore • Basophilic ... membrane disorder ... Diagnosis #Algorithm #workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... , lymphoma, idiopathic ... lymphoproliferative disorders ... • Intrinsic RBC ... Hemoglobinopathies (e.g. sickle cell
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
, monoblast, & lymphoid ... as white blood cell ... (depending on cell ... myeloproliferative disorders ... the underlying cause
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Workup: • Full ... platelets - WBC
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... Connective tissue disorders ... Thalassemia, Sickle cell ... anemia • Other
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... • Plasma cell neoplasms ... MM, the plasma cell ... • No CRAB - no anemia ... #Solitary #Cell
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