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hematology differential oncology hemolytic algorithm bands bloodcell castleman cell chronic classification disease extravascular gap globulin hemolysis hodgkins intravascular leucocytosis leukemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... IgM associated lymphoma ... #differential #diagnosis ... hematology #microscopy #atlas
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... changes), high MCV anemia ... not required in all ... #Causes #Workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... Lymphocytosis on CBC ... lymphoproliferative disorders ... • Neutropenia, anemia ... #workup #oncology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... thalassemia, S Lepore • Basophilic ... membrane disorder ... #Algorithm #workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... , lymphoma, idiopathic ... lymphoproliferative disorders ... • Intrinsic RBC
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
, monoblast, & lymphoid ... eosinophils, & basophils ... myeloproliferative disorders ... rickettsia infections, brucellosis ... the underlying cause
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Workup: • Full ... platelets - WBC
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... Connective tissue disorders ... anemia • Other ... #differential #diagnosis
CASTLEMAN DISEASE Disorder of the immune system with excessive production of IL-6 Castleman’s disease is a rare, heterogeneous
CASTLEMAN DISEASE Disorder ... CBC: Anemia and ... HHV-8 and HIV is crucial ... and may help in diagnosis ... Castleman #disease #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... • No CRAB - no anemia ... • CBC + diff • ... • Non-Hodgkin Lymphoma ... #Workup #Hematology
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