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diagnosis hematology differential hemolytic algorithm bands bloodcell classification extravascular gap globulin hodgkins intravascular leucocytosis leukemoidreaction management microscopy morphology neutrophils nomenclature
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... IgM associated lymphoma ... hematology #microscopy #atlas
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... ) (e.g. lupus, CLL ... , lymphoma, idiopathic ... lymphoproliferative disorders ... • Intrinsic RBC
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... thalassemia, S Lepore • Basophilic ... membrane disorder ... Diagnosis #Algorithm #workup
Evaluation of Leukocytosis: The term 'leukocyte' applies to any cells within the myeloblast, monoblast, & lymphoid lineages. Include
, monoblast, & lymphoid ... eosinophils, & basophils ... myeloproliferative disorders ... rickettsia infections, brucellosis ... the underlying cause
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Workup: • Full
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... Connective tissue disorders ... • Hematology: Lymphoma ... anemia • Other
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