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hematology differential oncology algorithm hemolytic testing arthritis bloodcell chronic classification extravascular folate folicacid gap globulin hemolysis hodgkins homocysteine intravascular laboratory
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... Target Cell RBC ... #differential #diagnosis ... hematology #microscopy #atlas
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... changes), high MCV anemia ... not required in all ... #Causes #Workup
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... the most likely cause ... recovery also causes ... #Diagnosis #Macrocytosis ... #AAFP
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Consider sickle cell ... membrane disorder ... #Algorithm #workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... • Intrinsic RBC
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... cells can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Myeloproliferative Disease ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... number of sites of disease
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... the presence of anemia ... metabolic or endocrine disorders ... (to support a diagnosis ... #diagnosis #testing
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Connective tissue disorders ... autoimmune hepatitis, PBC ... anemia • Other ... #differential #diagnosis
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