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diagnosis hematology differential algorithm macrocytic management aafp ascorbicacid bloodcell classification extravascular folate folicacid gap globulin hemolysis hodgkins homocysteine intravascular lymphoma
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Microangiopathic Hemolytic ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... hematology #microscopy #atlas
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... • Intrinsic RBC
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... membrane disorder ... #Anemia #Differential ... Diagnosis #Algorithm #workup
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... acute blood loss, hemolysis ... (BM) ablative disorders ... Algorithm #Diagnosis #Workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... #Workup #hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... Hemorrhage or hemolysis ... the most likely cause ... recovery also causes ... of the initial work-up
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
breath, wasting, anemia ... Loss of teeth Anemia ... beta-spectrin, which is crucial ... contribute to nonimmune hemolysis ... , or any other cause
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Hodgkin Lymphoma Workup
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... Connective tissue disorders ... autoimmune hepatitis, PBC ... anemia • Other
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