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diagnosis hematology differential oncology leukemia lymphocytic management rheumatology testing algorithm arthritis bloodcell causes classification dehydrogenase elevated erythematosus gap globulin hemeonc
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... Target Cell RBC ... hematology #microscopy #atlas
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... hypertension • Unusual RBC ... membrane disorder ... Diagnosis #Algorithm #workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... cells can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... PT, aPTT(liver disease ... changes), high MCV anemia ... not required in all ... Diagnosis #Causes #Workup
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... leukemia in adults • Disorder ... 5) Symptoms of anemia ... chemotherapy for low-risk disease
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
concentrations in: RBCs ... • Hemolytic Anemias ... disease, deficiency ... paralyses CNS Disorders ... differential #diagnosis #Laboratory
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... with: • Minimal laboratory ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... with Lupus: • Chronic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Marrow Failure • Chronic ... Myeloproliferative Disease ... Workup: • Complete
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... the presence of anemia ... Screening Tests for Chronic ... metabolic or endocrine disorders ... #workup #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... number of sites of disease
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