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diagnosis hematology oncology algorithm hemolytic morphology agglutinin bloodcell calcium causes chronic classification cold dehydrogenase disease disorders endocrinology erythematosus evaluation folate
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... #Morphology #differential ... hematology #microscopy #atlas
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... Atlas • Microcytic ... coagulopathy (DIC) #RBC ... #Morphology #Atlas ... key #diagnosis #differential
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... reticulocyte count is elevated ... of the initial work-up ... Homocysteine #Algorithm #Workup ... #AAFP
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... Elevated LDH 5. ... Elevated beta 2 ... Leukemia #diagnosis #workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... #Differential # ... Diagnosis #Algorithm #workup
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
a careful med rec ... Vit D • If all ... #differential # ... endocrinology #calcium #elevated ... #evaluation #workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Hyperbilirubinemia • Elevated ... Blood smear - RBC ... younger pts) Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... schistocytes, nucleated RBCs ... immune hemolytic anemia ... count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... concentrations in: RBCs ... • Hemolytic Anemias ... - Pernicious anemia ... #differential #
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... Diagnosis #Causes #Workup
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