21 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Hyperbilirubinemia • Elevated ... Blood smear - RBC ... younger pts) Differential
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... coagulopathy (DIC) #RBC ... #Morphology #Atlas ... key #diagnosis #differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... iron deficiency anemia ... Autoimmune hemolytic anemia ... #Morphology #differential ... hematology #microscopy #atlas
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... #Differential # ... Diagnosis #Algorithm #workup
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
with elevated Mean ... Volume (MCV) - Differential ... Neutrophils - Low RBC ... RBCs in Rouleaux ... #elevatedMCV #Differential
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
of macrocytic anemia ... (RBC = red blood ... reticulocyte count is elevated ... of the initial work-up ... Homocysteine #Algorithm #Workup
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... schistocytes, nucleated RBCs ... immune hemolytic anemia ... count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
a careful med rec ... Hypercalcemia #workup ... #differential # ... endocrinology #calcium #elevated ... #evaluation #workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... . primary cold agglutin ... • Intrinsic RBC ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Non-ACS Myocardial Injury - Elevated Troponin Differential Diagnosis and Workup Algorithm

 • Chronic Myocardial Injury: End
Myocardial Injury - Elevated ... Troponin Differential ... Diagnosis and Workup ... Shock, Hypoxemia, Anemia ... #Troponin #Differential