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diagnosis hematology chronic cll lymphocytic mds myelodysplastic aplastic b12 cell classification cobalamin deficiency differential gap globulin hemeonc hodgkins lymphoma myelodysplasia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... cytopenias (usually anemia ... transformation to acute leukemia ... Management • ... treatment #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Vmphocytosis on routine CBC ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology ... hemeonc #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
wt loss • If anemia ... • Labs: - CBC ... , PBS - anemia, ... diagnosis e.g. leukemia ... Deficiency #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Workup: • Complete ... diagnosis #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... classification #hematology #oncology ... #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... • Plasma cell leukemia ... autoimmune hepatitis, PBC ... Hematology: Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... • CBC + diff • ... #Plasmacytoma #Oncology ... #Diagnosis #Workup
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