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diagnosis hematology differential algorithm oncology macrocytic morphology bloodcell chronic classification cll folate folicacid gap globulin hemolytic hodgkins homocysteine key leukemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... Atlas • Microcytic ... - Sickle cell anemia ... coagulopathy (DIC) #RBC ... #Morphology #Atlas
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... disease Target Cell ... hematology #microscopy #atlas
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... Red cell distribution ... for degree of anemia ... Algorithm #Diagnosis #Workup
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... cell; MMA = methylmalonic ... of the initial work-up ... Homocysteine #Algorithm #Workup ... #AAFP
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle cells ... Consider sickle cell ... hypertension • Unusual RBC ... Diagnosis #Algorithm #workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... or basket cells ... and other C Cell ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... platelets - WBC
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... • Plasma cell neoplasms ... • No CRAB - no anemia ... • CBC + diff • ... Oncology #Diagnosis #Workup
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... autoimmune hepatitis, PBC ... Thalassemia, Sickle cell ... anemia • Other
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