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diagnosis differential hematology rheumatology oncology acute aki approach bloodcell classification cll disease erythematosus gap globulin joint kidneyinjury laboratory leukemia lupus
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... myeloma Rouleaux: Chronic ... Multiple myeloma, Chronic ... diagnosis #hematology #microscopy ... #atlas #nomenclature
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
rheumatic fever • Chronic ... Lyme), reactive arthritis ... hepatitis, herpes • Chronic ... SLE, psoriatic arthritis ... rheumatology #approach #workup
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... polarized light microscopy ... the presence of anemia ... Screening Tests for Chronic ... #laboratory #workup
Simplified Approach to Acute Kidney Injury (AKI) 1) IS THIS AN EMERGENCY? Is there a dialysis indication
e.g AEIOU ) or anuria ... Assess UA w/ microscopy ... for WBCs, RBCs, ... KidneyInjury #simplified #workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphocytosis on CBC ... • Neutropenia, anemia ... leukemia #CLL #Chronic ... Leukemia #diagnosis #workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... abnormal under the microscope ... abnormal under a microscope ... Workup: • Complete
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
PR3-ANCA): • Microscopic ... Eosinophilia, asthma, chronic ... and often causes arthritis ... Lab Tests: • CBC ... Dx: GPA, EGPA, microscopic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... lung syndrome Arthritis ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... with Lupus: • Chronic
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... (RA, Temporal arteritis ... autoimmune hepatitis, PBC ... Thalassemia, Sickle cell anemia
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