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diagnosis differential algorithm oncology dermatology generalized hemolytic pancytopenia pruritus secondary systemic agglutinin aplastic biliary cholangitis chronic cirrhosis cll cold disease
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... changes), high MCV anemia ... unclear, or if a primary ... #Workup #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Eating disorders ... Acquired Aplastic Anemia ... Primary hematological ... Diagnosis #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Eating disorders ... Acquired Aplastic Anemia ... Primary hematological ... Diagnosis #Algorithm #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgM) (e.g. primary ... • Intrinsic RBC ... differential #diagnosis #hematology ... #anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... antithymocyte globulin ... #oncology #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Causes == Primary ... renal failure/uremia ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... #generalized #dermatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... intralobular bile ducts causes ... Proximal limb muscle wasting ... cholangitis #diagnosis #workup ... #hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Cold Agglutinin Syndrome ... Positive Coombs testing ... Blood smear - RBC ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... Workup: • Complete ... Treatment: Goals: Treating ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... increase in gamma globulins ... Leukemia #diagnosis #workup ... #oncology #hematology
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