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Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
hypereosinophilia (HE) Caused ... cytokines Common causes ... disease Rare causes ... : - B or T cell ... CD3-CD4+ T cells
B/T Cell Development
This is a work in progress describing the maturation of B & T cells
B/T Cell Development ... maturation of B ... & T cells in a lymph ... #lymph node #b-cell ... #t-cell
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
responses, and B ... antigen activates B ... to the B-cell receptor ... paths, one using B ... Millions of different B
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
lymphocytes/Mature B ... cells can infiltrate ... indicate disease • B ... cell surface molecules ... AIHA • Pure red cell
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Involvement - B-cell ... CD10 - T-cell ... or λ), Smudge Cells ... - B-cell ... Thrombocytosis - T-cell
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
then stimulate B ... recognized by B ... fragment bind B ... complex and enhance B ... blood -> Memory B
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Lymphocytes - T or B ... 75% of ALL is of B-cell ... marrow • Mature B-cell ... -> AML: Blast crises ... Accumulation of Mature B
Inflammatory mechanism of asthma. 
Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Airway epithelial cells ... induce B-cell class ... TH2 cells also migrate ... eosinophils, mast cells ... submucosal mast cells
Acquired Immunodeficiency Syndrome (AIDS): Summary of Causes and Ocular Manifestations
 • Molluscum lesions
 • Eyelid Kaposi
AIDS): Summary of Causes ... Cellulitis • B-cell ... (dry eve) • B-cell
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Features of a Sickle Cell ... Crisis Sickle-cell ... These cells can ... Crises can be precipitated ... by Parvovirus B