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diagnosis differential oncology causes approach classification cll leukemia lymphocytic management mds mentzerindex myelodysplasia myelodysplastic rdw reticulocytes syndromes thrombocytes underproduction
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... with Pancytopenia ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... deficiency: • B12
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Differential Diagnosis Algorithm ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Differential Diagnosis Algorithm ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Diagnostic Algorithm ... - Anemia of chronic ... disease - Vitamin B12 ... #hematology #diagnosis ... #differential #workup
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... bone marrow + pancytopenia ... Difficulty breathing • Neutropenia ... #hematology #diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... Deficiency • B12 ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Pancytopenia is ... a hematologic condition ... hemoglobin of less than 12 ... primarily seen as neutropenia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... Pure red cell aplasia ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... Marrow Failure • Chronic ... Myeloproliferative Disease • Neutropenia ... Nutritional: vitamin B12 ... Syndromes #diagnosis #hematology
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