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diagnosis differential macrocytic aafp aplastic causes chronic cll folate folicacid hemolytic homocysteine leukemia lymphocytic macrocytosis management mds microcytic mma myelodysplasia
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... ITP • SLE • CLL ... #Causes #Hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the ... evaluation of macrocytic ... RBC = red blood cell ... of the initial work-up ... #Workup #AAFP
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
or basket cells ... • Neutropenia, anemia ... , thrombocytopenia ... Leukemia #diagnosis #workup ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... • Sickle cells ... Consider sickle cell ... Schistocytes, thrombocytopenia ... #workup #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... corpuscular (cell ... Red cell distribution ... (EPO), iron or B12 ... #Workup #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Nutritional: vitamin B12 ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... - Parvovirus B19 ... number of CD34+ cells ... • Parvovirus B19 ... #oncology #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... Diagnostic Evaluation ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology
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