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diagnosis algorithm hematology cobalamin macrocytic management aafp acidosis approach dementia elevatedmcv elevation fatigue folate folicacid geriatrics homocysteine ibd lactate lactic
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
the most likely cause ... recovery also causes ... of the initial work-up ... deficiency. ... #VitaminB12 #Folate
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Dietary Deficiency ... and Folate Deficiency ... #Macrocytosis #
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... (>100 fL) • B12 ... #MCV #Classification ... #Differential #
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... antagonists #VitaminB12 ... #cobalamin #differential
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... • B12/Folate ... Deficiency • Aplastic ... #Classification ... Diagnosis #Algorithm #Causes
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Crohn's > UC Anemia ... If persistent macrocytosis ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes •
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... hypersegmented neutrophils, macrocytosis ... #Cobalamin #Deficiency ... diagnosis #management #nutrition
Major neurocognitive disorders (MNCD): Diagnosis and workup 1) Clinical diagnosis Cognitive impairment + loss of autonomy 2)
Whipple, vitamin deficiency ... Alzheimer - 1st cause ... - Progressive amnesia ... MNCD #Dementia #Differential ... #Subtypes #Classification
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
deficiency. ... autoantibodies (pernicious anemia ... #VitaminB12 #deficiency ... #differential # ... diagnosis #hematology #nutrition
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