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diagnosis hematology causes algorithm pancytopenia acidosis aplastic approach cobalamin elevation fat fatigue fatrbc hodgkins ibd lactate lactic lymphoma macrocytic mcv
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... gestation • Vitamin B12 ... #Vitamins #Deficiency ... #differential # ... signs #symptoms #nutrition
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... (>100 fL) • B12 ... Deficiency • ... #MCV #Classification ... #Differential #
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... • B12/Folate ... Deficiency • Aplastic ... #Classification ... #Approach #Differential
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... wt loss • If anemia ... #Cobalamin #Deficiency ... #diagnosis #management ... #nutrition
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
, GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... #oncology #hematology ... #diagnosis #management
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
, Anemia • Prevalence ... Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... Algorithm #diagnosis #management
FAT RBC Mnemonic for Causes of Macrocytic Anemia (MCV > 100) F - Folate (Fetus) and B12 Deficiency
FAT RBC Mnemonic ... Folate (Fetus) and B12 ... Deficiency - Impairs ... #RBC #FATRBC #Mnemonic ... #Differential #
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
Deficiency • Inadequate ... deficiency. ... autoantibodies (pernicious anemia ... #differential # ... diagnosis #hematology #nutrition
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