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diagnosis neurology causes pancytopenia symptoms algorithm autoantibodies erythematosus evaluation falls fat fatrbc geriatrics lupus macrocytic management mds mimickers myelitis myelodysplasia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional ... deficiency: • ... B12/folate/combined
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Autoimmune Diseases: • Systemic ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... #Diagnosis #Hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... gestation • Vitamin B12 ... #differential # ... diagnosis #signs ... #symptoms #nutrition
FAT RBC Mnemonic for Causes of Macrocytic Anemia (MCV > 100) F - Folate (Fetus) and B12 Deficiency
FAT RBC Mnemonic ... Folate (Fetus) and B12 ... Deficiency - Impairs ... #Differential # ... Diagnosis #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Neurological 12% ... - Hemolytic anemia ... autoantibodies #signs ... #rheumatology
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
deficiency. ... autoantibodies (pernicious anemia ... #differential # ... diagnosis #hematology ... #nutrition
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... central nervous system ... endocrine: Vitamin B12 ... deficiency • ... Lack of UMN/LMN signs
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... blood count with differential ... Syndromes #diagnosis #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Bilateral signs ... antibodies • Nutritional ... Deficiency: - ... Vitamin B12, E, ... #differential
Evaluation of Recurrent Falls Core Concept: Maintaining an upright posture requires the integrated function of multiple systems. Disruption in
embolism - Severe anemia ... e.g., diabetic, B12 ... deficiency) ... positive Romberg sign ... Falls #Diagnosis #Differential
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