15 results
Causes of Vitamin B12 Deficiency - Cobalamin
Decreased Intake
Pancreas: Insufficiency
Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Stomach: Pernicious anemia ... #Deficiency #Cobalamin ... #differential #diagnosis
Causes of Low Vitamin B12 Levels
Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people
Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... #low #cobalamin ... #differential #diagnosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... (>100 fL) • B12 ... #MCV #Classification ... #Algorithm #Causes
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
Vitamin B12 (Cobalamin ... ) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... #Cobalamin #Deficiency
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... • B12/Folate ... Deficiency • Aplastic ... #Classification ... #Algorithm #Causes
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... restricted diet/deficiency ... /other causes • ... IBD #Algorithm #diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... oncology #hematology #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... Most cases diagnosed ... • Pernicious anemia ... /B12 deficiency ... Phosphatase: • Other causes
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
workup 1) Clinical ... Whipple, vitamin deficiency ... Alzheimer - 1st cause ... - Progressive amnesia ... Differential #Subtypes #Classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
- Differential Diagnosis ... malignancy, or thiamine deficiency ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency ... #typeb #classification