18 results
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... - Coagulation disorder ... Wernicke-Korsakoff syndrome ... gestation • Vitamin B12 ... diagnosis #signs #symptoms
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... • Pernicious anemia ... /B12 deficiency ... mineralization Symptoms ... respiratory failure • Neurologic
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Agglutinin Syndrome ... Viral Infection Clinical ... of anemia include ... • hemolytic anemia
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... result in permanent neurologic ... HIV) - Vitamin B12 ... , Copper deficiency ... Lower motor neuron symptoms
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
Spinal Cord Disorders ... neurological lesion: Clinical ... myelopathy - Vit B12 ... MCTD, Sjogren syndrome ... #diagnosis #neurology
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... dysfunction, and/or disorders ... intrinsic factor, IF) Clinical ... to manifest its symptoms ... , alcohol use, symptoms
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... • Improve the symptoms
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
N2O can cause a syndrome ... of the spinal cord ... deficiency. ... The classic clinical ... of pernicious anemia
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Bilateral signs and/or symptoms ... Check Vitamin B12 ... • Nutritional Deficiency ... diagnosis #management #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Non-neuromuscular disorder ... of the spinal cord ... endocrine: Vitamin B12 ... deficiency • ... • Inflammatory disorders