15 results
Approach to Hypoproliferative Macrocytic Anemia

 • 812, Folate Deficiency
 • MDS+
 • Hypothyroid
 • Liver Disease
Hypoproliferative Macrocytic ... Anemia812 ... , Folate Deficiency ... #Anemia #differential ... algorithm #hematology #workup
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Volume (MCV) - Differential ... • Drugs Oval Macrocytes ... • Dietary Deficiency ... and Folate Deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... morphologic #mcv #differential ... #diagnosis #causes
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
evaluation of macrocytic ... the most likely cause ... recovery also causes ... of the initial work-up ... deficiency.
Micronutrient Deficiencies After Gastric Bypass
Fat-Soluble Vitamins:
 • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
• Thiamine - Nausea ... oculomotor dysfunction, gait ... cardiomyopathy) • Folate - Macrocytic ... B12 - Macrocytic ... nutrition #table #differential
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... : • Worsening macrocytic ... parasthesias, gait
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
1) Clinical ... Whipple, vitamin deficiency ... Alzheimer - 1st cause ... - Progressive amnesia ... MNCD #Dementia #Differential
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic ... ) - Waddling gait ... Phosphatase: • Other causes
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Nutritional: vitamin B12 ... Workup: • Complete ... blood count with differential