11 results
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
reactivation of latent ... should be based on clinical ... status, and focal neurologic ... Demyelinating disease caused ... , limb ataxia, gait
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... • Improve the symptoms ... #oncology #hematology
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... parasthesias, gait ... consider IM or IV
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... restricted diet/deficiency ... symptoms even if ... wnl B12 Patient ... /other causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... membrane into the CNS ... • Pernicious anemia ... /B12 deficiency ... ) - Waddling gait
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
soles in 50% of cases ... exposure to or symptoms ... tabes dorsalis, gait ... similar to those of B12 ... deficiency.
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
neurological lesion: Clinical ... of injury • Gait ... Non-compressive Spinal Cord Causes ... myelopathy - Vit B12 ... disorders #diagnosis #neurology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
of lactate as a clinical ... malignancy, or thiamine deficiency ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency ... Ethylene glycol - HIV
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... syphilis, and HIV ... ) - Vitamin B12 ... , Copper deficiency ... Lower motor neuron symptoms
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... Transverse Myelitis - Clinical ... Hyperreflexia develops later ... simplex virus, HIV ... • Nutritional Deficiency