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diagnosis differential management algorithm cord spinalcord aids alkaline alp aplastic cobalamin disorders fatigue hematology hepatology hyophosphatasia ibd immune infections infectiousdiseases
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
reactivation of latent ... should be based on clinical ... status, and focal neurologic ... Demyelinating disease caused ... , limb ataxia, gait
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... of injury • Gait ... Cord Causes: 1 ... myelopathy - Vit B12 ... disorders #diagnosis #neurology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... • Improve the symptoms ... #oncology #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... parasthesias, gait ... consider IM or IV
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... Causes of spinal ... syphilis, and HIV ... ) - Vitamin B12 ... , Copper deficiency
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... restricted diet/deficiency ... symptoms even if ... wnl B12 Patient ... /other causes •
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Phosphatase Of Clinical ... membrane into the CNS ... • Pernicious anemia ... /B12 deficiency ... ) - Waddling gait
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... Transverse Myelitis - Clinical ... Hyperreflexia develops later ... • Infectious causes ... simplex virus, HIV
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
noncompliance • Clinical ... initiation Clinical ... pleural effusions, CNS ... blindness, or gait ... • Parvovirus B19
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